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2006 Mercedes-Benz E350 Problems and Recalls

Owners filed 400 complaints with NHTSA about the 2006 Mercedes-Benz E350, most often about the fuel system (55% of complaints, typically around 88,500 miles). It is the most complained-about E350 model year since 2000 and has 4 recalls.

Complaints400
Recalls4
Crashes reported14
Fires reported9
Injuries reported181 death reported

Most common 2006 Mercedes-Benz E350 problems

  1. Fuel system

    219 complaints · 55%

    Half of these problems showed up before 88,500 miles. Parts named most often: delivery, storage.

    Gas tank leaking causing gas to drain into back seat. Cost to replace was aprox 1000 for part alone. After going to mercedes, my other mechanic was looking at other used parts and found that all used parts had same issue and leaking for exact location. Upper portion of gas tank. Looking online, there are lots of these…
    Owner report to NHTSA, 2013, at 88,000 miles
    The contact owns a mercedes benz E350. The contact stated while driving various speeds, a strong odor of fuel emitted inside of the vehicle. The vehicle had not been diagnosed or repaired. The manufacturer was not notified of the problem. The approximate failure mileage was 90,000. The VIN was unavailable.
    Owner report to NHTSA, 2013, at 90,000 miles
  2. Engine

    72 complaints · 18%

    Half of these problems showed up before 92,000 miles. Parts named most often: engine, exhaust system.

    Po16, po17 needs to replace balanceshaft timing chain will cost 8-10k. Engine will fail if not replaced . There is a notice on this. Check engine light stays on. Mercedes refuse to pay , cover cost when it is manufacturer defect. The engine should last longer.
    Owner report to NHTSA, 2014, at 92,000 miles
    Balance shaft manufacturing defect causes gear teeth to wear prematurely. This is a internal engine component. Poor materials caused the camshaft sprocket teeth to wear out ? Thus this is a manufacturing problem. Internal engine components like balance shaft sprockets are meant to last at least 150000 miles on mb cars…
    Owner report to NHTSA, 2014, at 91,000 miles
  3. Brakes

    54 complaints · 14%

    Half of these problems showed up before 133,000 miles.

    The sbc brake system on my auto is showing a warning to send the car to the dealer. They told me I needed a new ABS system $2200.00. Many mercedes owners are having the same problems with the sbc brake system. The brakes are very difficult and dangerous to work on! The hydraulics should have a lifetime warranty.
    Owner report to NHTSA, 2017, at 133,000 miles
    When driving the vehicle and error code says depressed brake pressure esp and brakes go out call dealership they said there is record of it being fixed in 2005 but it still does not work.
    Owner report to NHTSA, 2019, at 133,000 miles
  4. Transmission

    37 complaints · 9%

    Half of these problems showed up before 72,500 miles. Parts named most often: automatic transmission.

    Engine/transmission was acting jerky and suddenly the car lost power to engine and the car broke on it's own doing causing the vehicle to swerve into the other lane. Luckily there were no cars behind or to the side of me as this would have surely caused an accident. Currently there is a class action law suit in place…
    Owner report to NHTSA, 2011, at 72,000 miles
    At 73,480 miles this 2006 mercedes has a faulty conductor plate valve that needs to be replaced. This faulty conductor plate/speed sensor causes the car not to shift from 1st to 2nd gear and instead spins without going into gear. This vehicle has been in motion while this occurs. At stop light, tried to accelerate…
    Owner report to NHTSA, 2017, at 73,480 miles
  5. Electrical

    19 complaints · 5%

    Half of these problems showed up before 67,000 miles. Parts named most often: wiring, instrument cluster/panel, software.

    2006 mercedes benz E350 cannot open the trunnk remotely or with the lever on the drivers door, both license plate lights and third brake light not working.
    Owner report to NHTSA, 2012, at 66,750 miles
    Check engine light illuminated followed by another light indicating check oil level at next refueling. Had vehicle immediately examined by mercedes benz dealer. Engine oil level okay. No codes came up for oil sensor. Car has 66,239 miles. Was told by mbz dealer that balance shaft needs replacement due to sprocket…
    Owner report to NHTSA, 2012, at 66,215 miles
  6. Air bags

    13 complaints · 3%

    Half of these problems showed up before 86,500 miles. Parts named most often: frontal, side/window.

    Srs system shut down on 2006 mercedes benz 350e 4-matic. Light came on dash notifying me of the failure of the system. Took to dealer who informed me of code 9103 "resistance in drivers airbag" informed that harness in steering column was designed too short and when steering wheel is telescoped out the wire will…
    Owner report to NHTSA, 2010, at 86,605 miles
    Srs light stays on. Scanned system and got a code 9103. Found there was a tsb issued by mercedes for a wiring problem and harness repair for this model. I don't think I should have to pay the 6 hrs labor for this repair. It was their fault in making the wiring harness too short for a steering colum that moves in and…
    Owner report to NHTSA, 2020, at 80,660 miles
  7. Other or unspecified

    10 complaints · 3%

    Half of these problems showed up before 72,500 miles.

    2006 mercedes benz model E350. Strong fuel odor emanating from rear area (trunk) of vehicle on the outside. Car would not start and towed by aaa to mercedes benz dealership/car repair. Aaa tow driver stated that the odor of gasoline was so strong he was tempted in calling the fire department. Mercedes benz service…
    Owner report to NHTSA, 2012, at 72,488 miles
    Vehicle often smells of gas fume. This problem has occurred intermittently since I first owned the car in 2012. It is very severe sometimes . I was unable to determine the source of the problem until the fuel pump began to malfunction and I took the car to a mechanic who informed that this was a known issue with this…
    Owner report to NHTSA, 2015, at 75,000 miles
  8. Visibility and wipers

    8 complaints · 2%

    Half of these problems showed up before 111,000 miles. Parts named most often: sun/moon roof assembly.

    The contact owns a 2006 Mercedes-Benz e-class. The contact stated that while driving at 50 MPH, without warning the sunroof detached from the vehicle. The vehicle was taken to the dealer (Mercedes-Benz of honolulu 818 kapiolani blvd, honolulu, hi 96813 ([phone]) which informed the contact that no remedy was available…
    Owner report to NHTSA, 2020, at 124,000 miles
    The contact's son owns a 2006 Mercedes-Benz E350. The contact stated that while his son was driving at an undisclosed speed, the sunroof detached and shattered on the roadway. The vehicle was not taken to the dealer or an independent mechanic. The vehicle was not repaired. After investigating the failure, the contact…
    Owner report to NHTSA, 2025, at 97,900 miles

Complaints are owner reports to NHTSA, not verified defects. One complaint can name several components, so shares add up to more than 100%.

2006 Mercedes-Benz E350 recalls

  1. Visibility and wipers: sun/moon roof assembly

    NHTSA 24V874000 · November 19, 2024 · 33,456 vehicles

    Risk: A detached sunroof panel can become a road hazard, increasing the risk of a crash.

    Fix: Dealers will inspect and replace the sunroof panel as necessary, free of charge. Owner notification letters were mailed january 10, 2025. Owners may contact mbusa customer service at 1-800-367-6372. This recall is an expansion of previous NHTSA recall number 22v-954. Mbusa's number for this recall is 2024120001/2/3.

    Full defect summary

    Mercedes-benz USA, llc (mbusa) is recalling certain 2001-2011 c-class, clk, e-class, and cls vehicles. Please see the recall report for a complete list of models and model years. The glass sunroof panel may not be properly secured and can detach.

  2. Visibility and wipers: sun/moon roof assembly

    NHTSA 22V954000 · December 23, 2022 · 131,653 vehicles

    Risk: A detached sunroof panel may become a road hazard, increasing the risk of a crash.

    Fix: Dealers will inspect and replace the sunroof panel as necessary free of charge. Owner notification letters were mailed february 3, 2023. Owners may contact mbusa customer service at 1-800-367-6372. This recall expands NHTSA recall number 19v-918. Mbusa's numbers for this recall are 2023010004, 2023010005, and 2023010006.

    Full defect summary

    Mercedes-benz USA, llc (mbusa) is recalling certain 2001-2011 c-class, clk, e-class, and cls vehicles. Please refer to mbusa's recall report for specific vehicle model details. The glass sunroof panel may not be properly secured and may detach.

  3. Visibility and wipers: sun/moon roof assembly

    NHTSA 21V196000 · March 19, 2021 · 11,356 vehicles

    Risk: A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash.

    Fix: Mbusa will notify owners, and dealers will inspect the glass panel bonding and replace the sliding roof, as necessary, free of charge. Owner letters were mailed may 7, 2021. Owners may contact mbusa customer service at 1-800-367-6372. This recall is an expansion of recall number 19v-918. Mbusa's number for this recall is 2021040012.

    Full defect summary

    Mercedes-benz USA, llc (mbusa) is recalling certain 2006-2007 c350, c230, c280, clk350, e320cdi, e350 wagon, e350, 2006 c55 amg, clk500, cls500, cls55 amg, e500 wagon, e500, e55 amg, 2007 clk550, cls550, cls63 amg, e550, e63 amg, and e63 wagon amg vehicles. The bonding between the glass panel and the sliding roof frame may deteriorate, possibly causing the glass panel to detach from the vehicle.

  4. Visibility and wipers: sun/moon roof assembly

    NHTSA 19V918000 · December 20, 2019 · 747,928 vehicles

    Risk: A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash.

    Fix: Mbusa will notify owners, and dealers will inspect the glass panel bonding and replace the sliding roof, as necessary, free of charge. The recall began july 10, 2020. Owners may contact mbusa customer service at 1-800-367-6372. Mbusa's number for this recall is 2020040011.

    Full defect summary

    Mercedes-benz USA, llc. (mbusa) is recalling certain 2001-2011 vehicles. The bonding between the glass panel and the sliding roof frame may deteriorate, possibly resulting in the glass panel detaching from the vehicle. For a full list of the affected models visit: https://static.NHTSA.gov/odi/rcl/2019/rmisc-19v918-4126.pdf

Recall repairs are free at any franchised dealer. Enter your VIN at nhtsa.gov/recalls to see which recalls are still open on your car.

NHTSA defect investigations

Questions about the 2006 Mercedes-Benz E350

What are the most common problems with the 2006 Mercedes-Benz E350?
By NHTSA owner complaints: fuel system (219 complaints, typically around 88,500 miles); engine (72 complaints, typically around 92,000 miles); brakes (54 complaints, typically around 133,000 miles).
How many recalls does the 2006 Mercedes-Benz E350 have?
4 recalls listed by NHTSA, the latest from November 19, 2024 (visibility and wipers). Check your VIN at nhtsa.gov/recalls to see which ones are still open on your car.
Is the 2006 a bad year for the Mercedes-Benz E350?
It is the most complained-about E350 model year since 2000, with 400 complaints. Complaint counts are not adjusted for how many cars were sold, so popular years collect more of them, and the newest years have had less time to.

Other Mercedes-Benz E350 years

Mercedes-Benz E350 problems by year